Patients with Ulcerative Colitis have Imbalanced Intestinal Microbiota, Study Finds

New study reports key microbial and metabolic alterations in the bowel of patients with Ulcerative colitis (UC), an autoimmune bowel disease.   Source Vigsnaes, LK. Microbiotas from UC patients display altered metabolism and … [Read more...]

What is Magnesium Stearate? Dr. Michael Ash Offers His Critical Scientific Appraisal

Magnesium stearate is the most common fatty acid in the diet

Reposted with permission by Michael Ash BSc DO ND Dip ION of Originally posted Nutri-Link Clinical Education on  July 4, 2012 under " Magnesium Stearate, Hypothesis, Nocebo and Adverse ‘Halo Effect’ – a Critical … [Read more...]

Feeling ‘Gutsy?’ There’s a Lot to Swallow…

Developments surrounding our understanding of the intestine and it’s associated microflora are contending to be the most exciting research topics of the decade. Almost weekly cutting-edge research emerges in this arena, furthering … [Read more...]

Endurance Training Without Diet Changes Improve Blood Lipoproteins in The Obese

View of size and shape of HDL particles

An exercise intervention trial published in the April 2012 Journal Obesity found that when obese individuals underwent a three day per week endurance exercise regime, improvements in blood levels of cardioprotective lipoprotein particles … [Read more...]

New Links Between Mom’s Digestive Medications and Childhood Asthma

Links between maternal dysbiosis and asthma

A new study published today in Alimentary Pharmacology and Therapeutics noted an association between prenatal exposure to proton pump inhibitors (PPIs) and childhood asthma. Of the near 200,000 Danish infants tracked between years 1996 and … [Read more...]

Delayed Gluten Exposure During Infancy Augments Later Life Immunological Response and Autoimmunity to Gluten

Bacteroides fragilis activates Treg cells

dysfunctional cross talk between innate and adaptive immunity…..could be influenced by the timing of gluten introduction into the diet.... and composition of the GI microbiota," notes Sellitto et al 2012. Alessio Fasano's group at … [Read more...]

Time to Rethink Toxicity, Says a New Endocrine Society Report

EDCs can mimic estrogen, pictured below On March 14th the Endocrine Society published a collaborative, 78 page report which elucidates an emerging paradigm shift in the field of environmental toxicology. The obsolete thinking that “the … [Read more...]

New Mechanisms Linking Dysbiosis to gastroesophageal reflux disease (GERD) and Barrett’s Esophagus

Dysbiosis leads to inflammation and bacterial penetration

Is dysbiosis of the upper-GI tract to blame for esophageal gastroesophageal reflux disease (GERD) and it's related conditions, Barrett's esophagus and adenocarcinoma? For the past four years we've known that individuals with GERD have … [Read more...]

The Role of Methyl Donor and Choline Deficiency in Lipid Synthesis: SREBP-1

SAMe and phosphatidylcholine deficiency stimulate cholesterol and lipid synthesis

Low Cellular Availability of Methyl Group donors and Choline Stimulate an Alternative Lipid Synthetic Pathway: The role of SREBP-1 in Lipid Biosynthesis ....nutritional or genetic conditions limiting SAMe or PC production may activate … [Read more...]

B Vitamin Myo-inositol, Insulin Resistance and Ovulatory Function

Myo-inositol the most abundant isomer of inositol- a B vitamin- in the body. Myo-inositol is a key intracellular signaling molecule responsible for optimal cellular glucose regulation, osmolarity, cell membrane integrity, and more (1). … [Read more...]

The Gut-Brain Axis Regulates Appetite and Satiety

The postprandial release of glucagon-like peptide 1 (GLP-1) from the intestinal neuroendocrine cells leads to reduced appetite and inhibition of food intake. Vickers et al. note, "GLPs are known to modify food intake, increase satiety, … [Read more...]

The End of the Triglyceride vs. Ethyl Ester Debate?

Do we still need to debate which form of marine-derived omega-3 fatty acid is superior? A research group at Stanford University published a 12 week, double-blinded, parallel-design, placebo-controlled trial comparing the … [Read more...]

Big Pharma Goes After Nrf2-Activating Compounds

Nrf2 Activation, Glutathione enhancement

As you may recall from our many "Nrf2-activating" discussions over the years, certain botanical compounds like sulforaphane glucosinolate, curcumin, resveratrol and green tea function to increase intracellular signaling of a key … [Read more...]