French researchers link dysbiosis of the blood with adverse cardiovascular events
Watch this video below to learn more!
CHOLESTEROL AND HEART DISEASE: BACTERIA ARE PARTOF THE STORY
Despite the huge progress in traditional heart disease risk factor reduction over the last several decades , the condition remains to be the leading cause of mortality in the US and many developing countries through out the globe. Historical and epidemiological evidence supports the hypothesis that microorganism burden initiates and precedes cardiovascular disease development. The strong link between periodontal disease and Chlamydia and heard disease is one such example. One such study recently quantified bacterial genetic material in both the oral mucosa and atherosclerotic plaque samples, finding strong correlating between bacterial common to both the oral cavity and gut inside the atherosclerotic plaque (Koren 2011). Suggesting that the atherosclerotic plaque microbiota may be derived from the oral cavity and/or the gut!
BACTERIA OF THE ORAL CAVITY
“…bacteria in the oral cavity and the gut correlated with plasma cholesterol levels. ….suggest that bacteria from the oral cavity, and perhaps even the gut, may correlate with disease markers of atherosclerosis.”
Additionally, other studies have linked increased blood levels of the bacterial cell wall appendage of known as endotoxin with both metabolic dysfunction, obesity AND carotid artery atherosclerosis development (Amar 2003).
ENDOTOXIN IS LINKED WITH ARTERIAL STIFFNESS
“… This population-based study yields first evidence that CD14 (an endotoxin receptor) is associated with aortic stiffness independently of age, BP and atherosclerosis in humans.
BACTERIAL IMBALANCES IN THE BLOOD STREAM LINKED WITH HEART DISEASE
“… Proteobacteria (an endotoxin harboring bacteria)…. were shown to be independent markers of the risk of cardiovascular disease…This finding is evidence for the new concept of the role played by blood microbiota dysbiosis on atherothrombotic disease.”
Now, in the most recent ground breaking study, a highly specific bacterial DNA marker (16s ribosomal DNA gene sequences) was misruled in the blood of some 3,936 participants of the D.E.S.I.R (Data from an Epidemiological Study on the Insulin Resistance syndrome). The conclusion of this large cohort study was that dysbiosis- or bacterial imbalance- in the blood stream predicted poor cardiovascular prognosis. More specifically, poor prognosis was associated with increased proportion of bacteria belonging to the Proteobacteria phylum, which harbor the pro-inflammatory bacterial appendage described above called endotoxin. Examples of these endotoxin Species of the Proteobacteria phylum include Salmonella, cholera, E. Coli and Hilicobacter.
Interesting, many other studies have linked increased blood levels of proteobacteria with obesity and type 2 diabetes- common co-morbidities of heart disease.
THE BEST STRATEGY TO REDUCE THE INTESTINAL ABSORPTION OF ENDOTOXIN ?
Moderate to low fat diet, high fiber- especially inulin-, bifidobacterium probiotics, the probiotics yeast saccharomyces, herbs such as resveratrol, curcumin, berberine and pterostilbene and oral immunoglubulins.
In my new book Belly Fat Effect: The Real Secret About How Your Diet, Intestinal Health, and Gut Bacteria Help You Burn Fat, I discuss the many ways to minimize leaky gut and endotoxin absorption. Click HERE to learn more about endotoxin
unraveling this endotoxin story for the improvement of chronic disease. To get more information just go to www.mikemutzel.com/Get-Science for more updates.
1) Koren, O., Spor, A., Felin, J., Fåk, F., Stombaugh, J., Tremaroli, V., Behre, C. J., et al. (2011). Colloquium Paper: Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proceedings of the National Academy of Sciences, 108(Supplement_1), 4592–4598. doi:10.1073/pnas.1011383107